Bioactive sorbicillinoid derivatives from an endophytic fungus Trichoderma citrinoviride
Three new sorbicillinoid derivatives, citrinsorbicillinol A-C (1–3), along with three known compounds, such as trichosorbicillin G (4), dibutyl phthalate (5), and 3-(4-methoxyphenyl) propanoic acid (6), were isolated from the endophyte Trichoderma citrinoviride of Coptis chinensis. Their structures...
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Microbiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmicb.2025.1485032/full |
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| author | Yan-Ping Xia Yan Xie Li Rao Guo-Ping Yin |
| author_facet | Yan-Ping Xia Yan Xie Li Rao Guo-Ping Yin |
| author_sort | Yan-Ping Xia |
| collection | DOAJ |
| description | Three new sorbicillinoid derivatives, citrinsorbicillinol A-C (1–3), along with three known compounds, such as trichosorbicillin G (4), dibutyl phthalate (5), and 3-(4-methoxyphenyl) propanoic acid (6), were isolated from the endophyte Trichoderma citrinoviride of Coptis chinensis. Their structures were elucidated through extensive analyses of spectroscopic data, computer-assisted structure elucidation (ACD/Structure Elucidator), density functional theory (DFT) calculations of the nuclear magnetic resonance (NMR) spectra, and electronic circular dichroism (ECD). Biologically, compounds 1–4 exhibited potential antioxidant activity, as assessed using the 1,1-diphenyl-2-picrylhydrazyl (DPPH) assay, with IC50 values ranging from 27.8 to 89.6 μM. In particular, compounds 2 and 3 demonstrated radical scavenging activity comparable to that of the positive control, ascorbic acid, with IC50 values of 27.8 and 31.2 μM, respectively. Moreover, compound 1 exhibited potential anti-inflammatory activity by inhibiting nitric oxide (NO) production in lipopolysaccharide (LPS)-induced RAW 264.7 macrophages, with an IC50 value of 52.7 μM. These findings underscore the therapeutic potential of the new sorbicillinoid derivatives for antioxidant and anti-inflammatory applications. |
| format | Article |
| id | doaj-art-f97068a209604667ae90a10d2eeb4a8e |
| institution | Kabale University |
| issn | 1664-302X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Microbiology |
| spelling | doaj-art-f97068a209604667ae90a10d2eeb4a8e2025-01-28T09:25:23ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2025-01-011610.3389/fmicb.2025.14850321485032Bioactive sorbicillinoid derivatives from an endophytic fungus Trichoderma citrinovirideYan-Ping Xia0Yan Xie1Li Rao2Guo-Ping Yin3Department of Pharmacy, Nanan People’s Hospital of Chongqing, Chongqing, ChinaDepartment of Pharmacy, Zhengzhou Shuqing Medical College, Zhengzhou, ChinaChongqing Key Laboratory of High Active Traditional Chinese Drug Delivery System, Chongqing Medical and Pharmaceutical College, Chongqing, ChinaEngineering Research Center of Coptis Development and Utilization (Ministry of Education), College of Pharmaceutical Sciences and Chinese Medicine, Southwest University, Chongqing, ChinaThree new sorbicillinoid derivatives, citrinsorbicillinol A-C (1–3), along with three known compounds, such as trichosorbicillin G (4), dibutyl phthalate (5), and 3-(4-methoxyphenyl) propanoic acid (6), were isolated from the endophyte Trichoderma citrinoviride of Coptis chinensis. Their structures were elucidated through extensive analyses of spectroscopic data, computer-assisted structure elucidation (ACD/Structure Elucidator), density functional theory (DFT) calculations of the nuclear magnetic resonance (NMR) spectra, and electronic circular dichroism (ECD). Biologically, compounds 1–4 exhibited potential antioxidant activity, as assessed using the 1,1-diphenyl-2-picrylhydrazyl (DPPH) assay, with IC50 values ranging from 27.8 to 89.6 μM. In particular, compounds 2 and 3 demonstrated radical scavenging activity comparable to that of the positive control, ascorbic acid, with IC50 values of 27.8 and 31.2 μM, respectively. Moreover, compound 1 exhibited potential anti-inflammatory activity by inhibiting nitric oxide (NO) production in lipopolysaccharide (LPS)-induced RAW 264.7 macrophages, with an IC50 value of 52.7 μM. These findings underscore the therapeutic potential of the new sorbicillinoid derivatives for antioxidant and anti-inflammatory applications.https://www.frontiersin.org/articles/10.3389/fmicb.2025.1485032/fullsorbicillinoidfungusTrichodermaantioxidantanti-inflammatory |
| spellingShingle | Yan-Ping Xia Yan Xie Li Rao Guo-Ping Yin Bioactive sorbicillinoid derivatives from an endophytic fungus Trichoderma citrinoviride Frontiers in Microbiology sorbicillinoid fungus Trichoderma antioxidant anti-inflammatory |
| title | Bioactive sorbicillinoid derivatives from an endophytic fungus Trichoderma citrinoviride |
| title_full | Bioactive sorbicillinoid derivatives from an endophytic fungus Trichoderma citrinoviride |
| title_fullStr | Bioactive sorbicillinoid derivatives from an endophytic fungus Trichoderma citrinoviride |
| title_full_unstemmed | Bioactive sorbicillinoid derivatives from an endophytic fungus Trichoderma citrinoviride |
| title_short | Bioactive sorbicillinoid derivatives from an endophytic fungus Trichoderma citrinoviride |
| title_sort | bioactive sorbicillinoid derivatives from an endophytic fungus trichoderma citrinoviride |
| topic | sorbicillinoid fungus Trichoderma antioxidant anti-inflammatory |
| url | https://www.frontiersin.org/articles/10.3389/fmicb.2025.1485032/full |
| work_keys_str_mv | AT yanpingxia bioactivesorbicillinoidderivativesfromanendophyticfungustrichodermacitrinoviride AT yanxie bioactivesorbicillinoidderivativesfromanendophyticfungustrichodermacitrinoviride AT lirao bioactivesorbicillinoidderivativesfromanendophyticfungustrichodermacitrinoviride AT guopingyin bioactivesorbicillinoidderivativesfromanendophyticfungustrichodermacitrinoviride |