In Silico Design, Optimization, and Evaluation of a Multi-Epitope Vaccine Targeting the <i>Clostridium perfringens</i> Collagen Adhesin Protein

In Silico Design, Optimization, and Evaluation of a Multi-Epitope Vaccine Targeting the <i>Clostridium perfringens</i> Collagen Adhesin Protein

Necrotic enteritis (NE), caused by pathogenic <i>Clostridium perfringens</i>, poses a significant threat to global poultry health, with estimated annual losses exceeding USD 6 billion. The rising incidence of NE has been associated with the reduced use of antibiotic growth promoters, und...

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Bibliographic Details
Main Authors: Dhiraj Chundru, Shailes Bhattrai, Madhusudan Timilsina, Hyun Lillehoj, Zhifeng Sun, Mostafa Ghanem, Charles Li
Format: Article
Language:English
Published: MDPI AG 2025-05-01
Series:Microorganisms
Subjects:
<i>Clostridium perfringens</i>
necrotic enteritis
collagen adhesin protein (CNA)
multi-epitope vaccine (MEV)
CD4<sup>+</sup> T cell
CD8<sup>+</sup> CTL
Online Access:https://www.mdpi.com/2076-2607/13/5/1147
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