CACNA1A loss-of-function affects neurogenesis in human iPSC-derived neural models

CACNA1A loss-of-function affects neurogenesis in human iPSC-derived neural models

Abstract CACNA1A encodes the pore-forming α1A subunit of the CaV2.1 calcium channel, whose altered function is associated with various neurological disorders, including forms of ataxia, epilepsy, and migraine. In this study, we generated isogenic iPSC-derived neural cultures carrying CACNA1A loss-of...

Full description

Saved in:
Bibliographic Details
Main Authors: Ilaria Musante, Davide Cangelosi, Lorenzo Muzzi, Fanny Jaudon, Marco Di Duca, Sara Guerrisi, Francesca Antonini, Yeraldin Chiquinquira Castillo De Spelorzi, Lorenzo A. Cingolani, Federico Zara, Paolo Scudieri
Format: Article
Language:English
Published: Springer 2025-06-01
Series:Cellular and Molecular Life Sciences
Subjects:
Neurodevelopmental diseases
In vitro models
Induced pluripotent stem cells
HD-MEA
ScRNA-seq
Online Access:https://doi.org/10.1007/s00018-025-05740-7
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://doi.org/10.1007/s00018-025-05740-7

Similar Items