Proteome‐Wide and Immune Cell Phenotype Mendelian Randomization Highlights Immune Involvement in Genetic Generalized Epilepsy

Proteome‐Wide and Immune Cell Phenotype Mendelian Randomization Highlights Immune Involvement in Genetic Generalized Epilepsy

ABSTRACT Introduction Genetic generalized epilepsy (GGE) involves polygenic inheritance, with emerging evidence implicating immune mechanisms in seizure pathogenesis. Unlike previous studies focusing on inflammation following seizures, we employed an integrative multi‐omics approach to identify prec...

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Bibliographic Details
Main Authors: Jianxiong Gui, Hongyuan Chu, Junjiao Zhang, Xiao Li, Wenwei Liu, Renqiuguo Li, Fan Zhang, Meiyu Dong, Kai Gao, Huaxia Luo, Yuwu Jiang
Format: Article
Language:English
Published: Wiley 2025-06-01
Series:Brain and Behavior
Subjects:
genetic generalized epilepsy
Mendelian randomization
plasma proteins
Online Access:https://doi.org/10.1002/brb3.70625
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