Structural insights into the activation mechanism of the human zinc-activated channel

Structural insights into the activation mechanism of the human zinc-activated channel

Abstract The zinc-activated channel (ZAC) is an atypical mammalian cys-loop receptor (CLR) that is activated by zinc ions and protons, allowing cations to pass through. The molecular mechanism that ligands use to activate ZAC remains elusive. Here, we present three cryo-electron microscopy reconstru...

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Main Authors: Xuhang Lu, Dongmei Li, Yaojie Wang, Gaohua Zhang, Tianlei Wen, Yue Lu, Nan Jia, Xuedi Wang, Shenghai Chang, Xing Zhang, Jianping Lin, Yu-hang Chen, Xue Yang, Yuequan Shen
Format: Article
Language:English
Published: Nature Portfolio 2025-01-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-55807-5
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