Distinct effects of IL-18 on the engraftment and function of human effector CD8 T cells and regulatory T cells.

Distinct effects of IL-18 on the engraftment and function of human effector CD8 T cells and regulatory T cells.

IL-18 has pleotropic effects on the activation of T cells during antigen presentation. We investigated the effects of human IL-18 on the engraftment and function of human T cell subsets in xenograft mouse models. IL-18 enhanced the engraftment of human CD8(+) effector T cells and promoted the develo...

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Main Authors: Richard G Carroll, Carmine Carpenito, Xiaochuan Shan, Gwenn Danet-Desnoyers, Ronghua Liu, Shuguang Jiang, Steven M Albelda, Tatiana Golovina, George Coukos, James L Riley, Zdenka L Jonak, Carl H June
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2008-09-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0003289&type=printable
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https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0003289&type=printable

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