Thiopurine methyltransferase polymorphisms in children with acute lymphoblastic leukemia

Thiopurine methyltransferase polymorphisms in children with acute lymphoblastic leukemia

Introduction: Acute lymphoblastic leukemia (ALL) is the most common malignancy in children. 6-mercaptopurine (6-MP) and methotrexate are backbone drugs for maintenance phase of treatment. Purine Analogs 6-MP/6-thioguanine/azathiopurine are metabolized to its inactive form by the enzyme thiopurine me...

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Main Authors: Vijay Gandhi Linga, Dorra Babu Patchva, Krishna Mohan Mallavarapu Venkata Tulasi, Krishnamani Iyer Kalpathi, Ashok Pillai, Sadashivudu Gundeti, Senthil J Rajappa, Raghunadharao Digumarti
Format: Article
Language:English
Published: Thieme Medical and Scientific Publishers Pvt. Ltd. 2014-01-01
Series:Indian Journal of Medical and Paediatric Oncology
Subjects:
Acute lymphoblastic leukemia
thiopurine methyltransferase
myelosuppression
Online Access:http://www.ijmpo.org/article.asp?issn=0971-5851;year=2014;volume=35;issue=4;spage=276;epage=280;aulast=Linga
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http://www.ijmpo.org/article.asp?issn=0971-5851;year=2014;volume=35;issue=4;spage=276;epage=280;aulast=Linga

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