Electroconvulsive therapy generates a postictal wave of spreading depolarization in mice and humans

Electroconvulsive therapy generates a postictal wave of spreading depolarization in mice and humans

Abstract Electroconvulsive therapy (ECT) is a fast-acting, highly effective, and safe treatment for medication-resistant depression. Historically, the clinical benefits of ECT have been attributed to generating a controlled seizure; however, the underlying neurobiology is understudied and unresolved...

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Main Authors: Zachary P. Rosenthal, Joseph B. Majeski, Ala Somarowthu, Davin K. Quinn, Britta E. Lindquist, Mary E. Putt, Antoneta Karaj, Chris G. Favilla, Wesley B. Baker, Golkoo Hosseini, Jenny P. Rodriguez, Mario A. Cristancho, Yvette I. Sheline, C. William Shuttleworth, Christopher C. Abbott, Arjun G. Yodh, Ethan M. Goldberg
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-59900-1
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https://doi.org/10.1038/s41467-025-59900-1

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