Mitochonic acid 5 mitigates age-related hearing loss progression by targeting defective 2-methylthiolation in mitochondrial transfer RNAs

Mitochonic acid 5 mitigates age-related hearing loss progression by targeting defective 2-methylthiolation in mitochondrial transfer RNAs

IntroductionAge-related hearing loss (ARHL) is linked to dementia, with mitochondrial dysfunction playing a key role in its progression. Deficient mitochondrial tRNA modifications impair protein synthesis and energy metabolism, accelerating ARHL. Mitochonic acid 5 (MA-5) has shown promise as a thera...

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Bibliographic Details
Main Authors: Teppei Kouga, Toru Miwa, Fan-yan Wei, Kishiko Sunami, Kazuhito Tomizawa
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-04-01
Series:Frontiers in Cellular Neuroscience
Subjects:
age-related hearing loss
mitochonic acid 5
mitochondrial dysfunction
cyclin-dependent kinase 5 regulatory subunit-associated protein 1
2-methylthiolation
Online Access:https://www.frontiersin.org/articles/10.3389/fncel.2025.1541347/full
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https://www.frontiersin.org/articles/10.3389/fncel.2025.1541347/full

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