Recombinant Expression of a Ready‐to‐Use EGF Variant Equipped With a Single Conjugation Site for Click‐Chemistry

Recombinant Expression of a Ready‐to‐Use EGF Variant Equipped With a Single Conjugation Site for Click‐Chemistry

ABSTRACT The epidermal growth factor (EGF) receptor is commonly targeted in cancer therapy because it is overexpressed in many malignant cells. However, a general problem is to couple the targeting moieties and the drug molecules in a way that results in a homogeneous product. Here, we overcome this...

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Bibliographic Details
Main Authors: Melanie Krass, Meike Kolster, José Ignacio Valenzuela, Lena Moldenhauer, Marten Kagelmacher, Nicole Niesler, Alexander Weng, Marino Zerial, Gregor Nagel, Hendrik Fuchs
Format: Article
Language:English
Published: Wiley-VCH 2025-03-01
Series:Engineering in Life Sciences
Subjects:
click‐chemistry
epidermal growth factor
ligand variant
single conjugation site
targeted therapy
Online Access:https://doi.org/10.1002/elsc.70015
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https://doi.org/10.1002/elsc.70015

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