Airway epithelial specific deletion of Jun-N-terminal kinase 1 attenuates pulmonary fibrosis in two independent mouse models.

Airway epithelial specific deletion of Jun-N-terminal kinase 1 attenuates pulmonary fibrosis in two independent mouse models.

The stress-induced kinase, c-Jun-N-terminal kinase 1 (JNK1) has previously been implicated in the pathogenesis of lung fibrosis. However, the exact cell type(s) wherein JNK1 exerts its pro-fibrotic role(s) remained enigmatic. Herein we demonstrate prominent activation of JNK in bronchial epithelia u...

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Bibliographic Details
Main Authors: Jos L van der Velden, John F Alcorn, David G Chapman, Lennart K A Lundblad, Charles G Irvin, Roger J Davis, Kelly Butnor, Yvonne M W Janssen-Heininger
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2020-01-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0226904&type=printable
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https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0226904&type=printable

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