Differences in clinical significance of atrial tachyarrhythmias in idiopathic ventricular fibrillation vs Brugada syndrome: A multicenter study
Background: Atrial tachyarrhythmias (ATAs) are the primary cause of inappropriate implantable cardioverter-defibrillator (ICD) therapy in patients with idiopathic ventricular fibrillation (IVF) and are associated with decreased quality of life and increased mortality. Nonetheless, the incidence of A...
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Elsevier
2024-11-01
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| Series: | Heart Rhythm O2 |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666501824002927 |
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| author | Tomofumi Mizuno, MD Nobuhiro Nishii, MD, PhD Hiroshi Morita, MD, PhD Takuro Masuda, MD Akira Ueoka, MD, PhD Saori Asada, MD, PhD Yoshimasa Morimoto, MD Masakazu Miyamoto, MD Satoshi Kawada, MD, PhD Tadashi Wada, MD, PhD Shigeki Hiramatsu, MD, PhD Keisuke Okawa, MD Motoki Kubo, MD, PhD Koji Nakagawa, MD, PhD Atsuyuki Watanabe, MD, PhD Kazufumi Nakamura, MD, PhD Shinsuke Yuasa, MD, PhD |
| author_facet | Tomofumi Mizuno, MD Nobuhiro Nishii, MD, PhD Hiroshi Morita, MD, PhD Takuro Masuda, MD Akira Ueoka, MD, PhD Saori Asada, MD, PhD Yoshimasa Morimoto, MD Masakazu Miyamoto, MD Satoshi Kawada, MD, PhD Tadashi Wada, MD, PhD Shigeki Hiramatsu, MD, PhD Keisuke Okawa, MD Motoki Kubo, MD, PhD Koji Nakagawa, MD, PhD Atsuyuki Watanabe, MD, PhD Kazufumi Nakamura, MD, PhD Shinsuke Yuasa, MD, PhD |
| author_sort | Tomofumi Mizuno, MD |
| collection | DOAJ |
| description | Background: Atrial tachyarrhythmias (ATAs) are the primary cause of inappropriate implantable cardioverter-defibrillator (ICD) therapy in patients with idiopathic ventricular fibrillation (IVF) and are associated with decreased quality of life and increased mortality. Nonetheless, the incidence of ATAs in IVF cases has not been clarified. Objective: The study sought to determine the incidence and clinical significance of ATAs in patients with IVF compared with those with Brugada syndrome (BrS). Methods: Patients diagnosed with IVF or BrS and receiving ICDs in 6 hospitals were enrolled between February 1997 and July 2020 to compute data regarding the incidence of ATAs, appropriate/inappropriate ICD therapy frequency, and independent predictors of ATAs. Results: Overall, 137 patients (51 in the IVF group and 86 in the BrS group) were enrolled. ATAs were detected in 22 (43.1%) patients in the IVF group and 17 (19.8%) in the BrS group (P = .006). Inappropriate ICD therapies due to ATAs were more frequently observed in the IVF group than in the BrS group (12 [23.5%] vs 7 [8.1%]; P = .020). Conversely, there was no significant difference in appropriate ICD therapies between the IVF and BrS groups (14 [27.5%] vs 23 [27.1%]; P = 1.000). Cox regression analysis revealed no predictive factors for the development of ATAs in the IVF group. Conclusion: ATA events were observed more frequently in patients with IVF than in those with BrS, and ATAs led to inappropriate ICD therapy in patients with IVF. Clinicians need to consider the recurrence of not only ventricular arrhythmias, but also the development of atrial arrhythmias for better management of IVF cases. |
| format | Article |
| id | doaj-art-f8ce72dc7a5c48c989ae24ff9536c1a9 |
| institution | Kabale University |
| issn | 2666-5018 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heart Rhythm O2 |
| spelling | doaj-art-f8ce72dc7a5c48c989ae24ff9536c1a92024-11-22T07:39:06ZengElsevierHeart Rhythm O22666-50182024-11-01511796804Differences in clinical significance of atrial tachyarrhythmias in idiopathic ventricular fibrillation vs Brugada syndrome: A multicenter studyTomofumi Mizuno, MD0Nobuhiro Nishii, MD, PhD1Hiroshi Morita, MD, PhD2Takuro Masuda, MD3Akira Ueoka, MD, PhD4Saori Asada, MD, PhD5Yoshimasa Morimoto, MD6Masakazu Miyamoto, MD7Satoshi Kawada, MD, PhD8Tadashi Wada, MD, PhD9Shigeki Hiramatsu, MD, PhD10Keisuke Okawa, MD11Motoki Kubo, MD, PhD12Koji Nakagawa, MD, PhD13Atsuyuki Watanabe, MD, PhD14Kazufumi Nakamura, MD, PhD15Shinsuke Yuasa, MD, PhD16Department of Cardiovascular Medicine, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan; Address reprint requests and correspondence: Dr Tomofumi Mizuno, Department of Cardiovascular Medicine, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Kita-ku, Okayama 700-8558, Japan.Department of Cardiovascular Therapeutics, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, JapanDepartment of Cardiovascular Therapeutics, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, JapanDepartment of Cardiovascular Medicine, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, JapanDepartment of Cardiovascular Medicine, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, JapanDepartment of Cardiovascular Medicine, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, JapanDepartment of Cardiovascular Medicine, Fukuyama City Hospital, Fukuyama, JapanDepartment of Cardiovascular Medicine, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, JapanDepartment of Cardiovascular Medicine, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, JapanDepartment of Cardiovascular Medicine, Iwakuni Clinical Center, Iwakuni, JapanDepartment of Cardiovascular Medicine, Fukuyama Cardiovascular Hospital, Fukuyama, JapanDepartment of Cardiovascular Medicine, Kagawa Prefectural Central Hospital, Takamatsu, JapanDepartment of Cardiovascular Medicine, Tsuyama Central Hospital, Tsuyama, JapanDepartment of Cardiovascular Medicine, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, JapanDepartment of Cardiovascular Medicine, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, JapanDepartment of Cardiovascular Medicine, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, JapanDepartment of Cardiovascular Medicine, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, JapanBackground: Atrial tachyarrhythmias (ATAs) are the primary cause of inappropriate implantable cardioverter-defibrillator (ICD) therapy in patients with idiopathic ventricular fibrillation (IVF) and are associated with decreased quality of life and increased mortality. Nonetheless, the incidence of ATAs in IVF cases has not been clarified. Objective: The study sought to determine the incidence and clinical significance of ATAs in patients with IVF compared with those with Brugada syndrome (BrS). Methods: Patients diagnosed with IVF or BrS and receiving ICDs in 6 hospitals were enrolled between February 1997 and July 2020 to compute data regarding the incidence of ATAs, appropriate/inappropriate ICD therapy frequency, and independent predictors of ATAs. Results: Overall, 137 patients (51 in the IVF group and 86 in the BrS group) were enrolled. ATAs were detected in 22 (43.1%) patients in the IVF group and 17 (19.8%) in the BrS group (P = .006). Inappropriate ICD therapies due to ATAs were more frequently observed in the IVF group than in the BrS group (12 [23.5%] vs 7 [8.1%]; P = .020). Conversely, there was no significant difference in appropriate ICD therapies between the IVF and BrS groups (14 [27.5%] vs 23 [27.1%]; P = 1.000). Cox regression analysis revealed no predictive factors for the development of ATAs in the IVF group. Conclusion: ATA events were observed more frequently in patients with IVF than in those with BrS, and ATAs led to inappropriate ICD therapy in patients with IVF. Clinicians need to consider the recurrence of not only ventricular arrhythmias, but also the development of atrial arrhythmias for better management of IVF cases.http://www.sciencedirect.com/science/article/pii/S2666501824002927Idiopathic ventricular fibrillationBrugada syndromeAtrial tachyarrhythmiasAtrial fibrillationImplantable cardioverter-defibrillatorInappropriate therapy |
| spellingShingle | Tomofumi Mizuno, MD Nobuhiro Nishii, MD, PhD Hiroshi Morita, MD, PhD Takuro Masuda, MD Akira Ueoka, MD, PhD Saori Asada, MD, PhD Yoshimasa Morimoto, MD Masakazu Miyamoto, MD Satoshi Kawada, MD, PhD Tadashi Wada, MD, PhD Shigeki Hiramatsu, MD, PhD Keisuke Okawa, MD Motoki Kubo, MD, PhD Koji Nakagawa, MD, PhD Atsuyuki Watanabe, MD, PhD Kazufumi Nakamura, MD, PhD Shinsuke Yuasa, MD, PhD Differences in clinical significance of atrial tachyarrhythmias in idiopathic ventricular fibrillation vs Brugada syndrome: A multicenter study Heart Rhythm O2 Idiopathic ventricular fibrillation Brugada syndrome Atrial tachyarrhythmias Atrial fibrillation Implantable cardioverter-defibrillator Inappropriate therapy |
| title | Differences in clinical significance of atrial tachyarrhythmias in idiopathic ventricular fibrillation vs Brugada syndrome: A multicenter study |
| title_full | Differences in clinical significance of atrial tachyarrhythmias in idiopathic ventricular fibrillation vs Brugada syndrome: A multicenter study |
| title_fullStr | Differences in clinical significance of atrial tachyarrhythmias in idiopathic ventricular fibrillation vs Brugada syndrome: A multicenter study |
| title_full_unstemmed | Differences in clinical significance of atrial tachyarrhythmias in idiopathic ventricular fibrillation vs Brugada syndrome: A multicenter study |
| title_short | Differences in clinical significance of atrial tachyarrhythmias in idiopathic ventricular fibrillation vs Brugada syndrome: A multicenter study |
| title_sort | differences in clinical significance of atrial tachyarrhythmias in idiopathic ventricular fibrillation vs brugada syndrome a multicenter study |
| topic | Idiopathic ventricular fibrillation Brugada syndrome Atrial tachyarrhythmias Atrial fibrillation Implantable cardioverter-defibrillator Inappropriate therapy |
| url | http://www.sciencedirect.com/science/article/pii/S2666501824002927 |
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