Cardiorenal ketone metabolism in healthy humans assessed by 11C-acetoacetate PET: effect of D-β-hydroxybutyrate, a meal, and age

Cardiorenal ketone metabolism in healthy humans assessed by 11C-acetoacetate PET: effect of D-β-hydroxybutyrate, a meal, and age

The heart and kidney have a high energy requirement, but relatively little is known about their utilization of ketones as a potential energy source. We assessed the metabolism of the ketone tracer, carbon-11 acetoacetate (11C-AcAc), by the left and right ventricles of the heart and by the kidney usi...

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Bibliographic Details
Main Authors: Valérie St-Pierre, Gabriel Richard, Etienne Croteau, Mélanie Fortier, Camille Vandenberghe, André C. Carpentier, Bernard Cuenoud, Stephen C. Cunnane
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-10-01
Series:Frontiers in Physiology
Subjects:
heart
kidney
metabolism
ketones
cardiorenal
positron emission tomography
Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2024.1443781/full
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https://www.frontiersin.org/articles/10.3389/fphys.2024.1443781/full

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