Assessment of Platelet Aggregation and Thrombin Generation in Patients with Familial Chylomicronemia Syndrome Treated with Volanesorsen: A Cross-Sectional Study

Assessment of Platelet Aggregation and Thrombin Generation in Patients with Familial Chylomicronemia Syndrome Treated with Volanesorsen: A Cross-Sectional Study

Background: The antisense oligonucleotide against APOC3 mRNA volanesorsen was recently introduced to treat Familial Chylomicronemia Syndrome (FCS). Cases of decreased platelet count are reported among patients treated with volanesorsen. The aim of the study was to evaluate platelet function and thro...

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Main Authors: Ilenia Lorenza Calcaterra, Renata Santoro, Nicoletta Vitelli, Ferdinando Cirillo, Guido D’Errico, Cornelia Guerrino, Giovanna Cardiero, Maria Donata Di Taranto, Giuliana Fortunato, Gabriella Iannuzzo, Matteo Nicola Dario Di Minno
Format: Article
Language:English
Published: MDPI AG 2024-09-01
Series:Biomedicines
Subjects:
familial chylomicronemia syndrome
severe hypertriglyceridemia
volanesorsen
antisense oligonucleotide
platelets
thrombin generation
Online Access:https://www.mdpi.com/2227-9059/12/9/2017
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