A Schistosomiasis Model with Praziquantel Resistance
A compartmental model is established for schistosomiasis with praziquantel resistance. The model considers the impact of genetic resistance and drug treatment on the transmission of schistosomiasis. We calculate the basic reproductive number and discuss the existence and stability of disease-free eq...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Discrete Dynamics in Nature and Society |
| Online Access: | http://dx.doi.org/10.1155/2013/945767 |
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| _version_ | 1832556788719812608 |
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| author | Longxing Qi Jing-an Cui |
| author_facet | Longxing Qi Jing-an Cui |
| author_sort | Longxing Qi |
| collection | DOAJ |
| description | A compartmental model is established for schistosomiasis with praziquantel resistance. The model considers the impact of genetic resistance and drug treatment on the transmission of schistosomiasis. We calculate the basic reproductive number and discuss the existence and stability of disease-free equilibrium, boundary equilibrium, and coexistence equilibrium. Our analysis shows that regardless of whether drug treatment leads to the emergence of resistance, once the impact of genetic resistance is larger, the resistant strain will be dominant, which is detrimental to the control of schistosomiasis. In addition, once the proportion of human with drug-resistant strain produced by drug treatment is larger, the number of human and snails with resistant strain is larger. This is not a good result for drug treatment with praziquantel. |
| format | Article |
| id | doaj-art-f8ae14d52eb94e83ac532a8f876d3aa0 |
| institution | Kabale University |
| issn | 1026-0226 1607-887X |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Discrete Dynamics in Nature and Society |
| spelling | doaj-art-f8ae14d52eb94e83ac532a8f876d3aa02025-02-03T05:44:29ZengWileyDiscrete Dynamics in Nature and Society1026-02261607-887X2013-01-01201310.1155/2013/945767945767A Schistosomiasis Model with Praziquantel ResistanceLongxing Qi0Jing-an Cui1School of Mathematical Sciences, Anhui University, Hefei 230601, ChinaCollege of Science, Beijing University of Civil Engineering and Architecture, Beijing 100044, ChinaA compartmental model is established for schistosomiasis with praziquantel resistance. The model considers the impact of genetic resistance and drug treatment on the transmission of schistosomiasis. We calculate the basic reproductive number and discuss the existence and stability of disease-free equilibrium, boundary equilibrium, and coexistence equilibrium. Our analysis shows that regardless of whether drug treatment leads to the emergence of resistance, once the impact of genetic resistance is larger, the resistant strain will be dominant, which is detrimental to the control of schistosomiasis. In addition, once the proportion of human with drug-resistant strain produced by drug treatment is larger, the number of human and snails with resistant strain is larger. This is not a good result for drug treatment with praziquantel.http://dx.doi.org/10.1155/2013/945767 |
| spellingShingle | Longxing Qi Jing-an Cui A Schistosomiasis Model with Praziquantel Resistance Discrete Dynamics in Nature and Society |
| title | A Schistosomiasis Model with Praziquantel Resistance |
| title_full | A Schistosomiasis Model with Praziquantel Resistance |
| title_fullStr | A Schistosomiasis Model with Praziquantel Resistance |
| title_full_unstemmed | A Schistosomiasis Model with Praziquantel Resistance |
| title_short | A Schistosomiasis Model with Praziquantel Resistance |
| title_sort | schistosomiasis model with praziquantel resistance |
| url | http://dx.doi.org/10.1155/2013/945767 |
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