Cytoplasmic HMGB2 orchestrates CALR translocation in the course of immunogenic cell death

A recent in vitro study showed that pharmacological inhibition of the nuclear export receptor XPO1 suppresses oxaliplatin-induced nuclear release of HMGB1 and HMGB2, as well as the translocation of CALR to the plasma membrane. Moreover, cell-targeted-HMGB2 protein potently induced CALR exposure, eve...

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Bibliographic Details
Main Authors: Peng Liu, Liwei Zhao, Oliver Kepp, Guido Kroemer
Format: Article
Language:English
Published: Taylor & Francis Group 2024-12-01
Series:OncoImmunology
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Online Access:https://www.tandfonline.com/doi/10.1080/2162402X.2024.2421028
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