SNAr Reactive Pyrazine Derivatives as p53-Y220C Cleft Binders with Diverse Binding Modes

SNAr Reactive Pyrazine Derivatives as p53-Y220C Cleft Binders with Diverse Binding Modes

Theresa Klett,1 Jason Stahlecker,1 Martin Schwer,1 Simon J Jaag,2 Benedikt Masberg,2 Cornelius Knappe,2 Michael Lämmerhofer,2 Thilo Stehle,3 Frank M Boeckler1,4 1Laboratory for Molecular Design & Pharmaceutical Biophysics, Institute of Pharmaceutical Sciences, Department of Pharmacy and Bioc...

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Bibliographic Details
Main Authors: Klett T, Stahlecker J, Schwer M, Jaag SJ, Masberg B, Knappe C, Lämmerhofer M, Stehle T, Boeckler FM
Format: Article
Language:English
Published: Dove Medical Press 2025-06-01
Series:Drug Design, Development and Therapy
Subjects:
tumor suppressor p53 mutant stabilizers
covalent fragment-based drug discovery
structure-activity relationship
differential scanning fluorimetry
intact protein mass spectrometry
X-ray crystallography
Online Access:https://www.dovepress.com/snar-reactive-pyrazine-derivatives-as-p53-y220c-cleft-binders-with-div-peer-reviewed-fulltext-article-DDDT
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