Case Report: Zolbetuximab-induced gastritis with protein-losing gastroenteropathy and hypogammaglobulinemia: a case implicating IgA vasculitis

Case Report: Zolbetuximab-induced gastritis with protein-losing gastroenteropathy and hypogammaglobulinemia: a case implicating IgA vasculitis

Zolbetuximab (ZOL), a monoclonal antibody targeting Claudin-18.2, is a promising therapeutic agent for the treatment of advanced gastric cancer. We report the first case of ZOL-induced acute gastritis leading to protein-losing gastroenteropathy, characterized by severe hypogammaglobulinemia and hypo...

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Bibliographic Details
Main Authors: Yasuhiro Mitsui, Yasushi Sato, Ryo Shinomiya, Satoshi Sumida, Shota Fujimoto, Akiko Okada, Takeshi Mitsuhashi, Tomoyuki Kawaguchi, Kaizo Kagemoto, Yoshifumi Kida, Koichi Okamoto, Hisanori Uehara, Tetsuji Takayama
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Oncology
Subjects:
gastric cancer
zolbetuximab
Claudin-18.2
gastritis
protein-losing gastroenteropathy
hypogammaglobulinemia
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2025.1644263/full
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https://www.frontiersin.org/articles/10.3389/fonc.2025.1644263/full

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