Utilizing native nanodiscs to isolate active TRPC3 channels and expand structural analysis capabilities

Utilizing native nanodiscs to isolate active TRPC3 channels and expand structural analysis capabilities

Abstract Recent advances in structural biology have provided insights into TRPC3, a TRP family member involved in various (patho)physiological processes. However, the lack of structural information on the channel’s open pore hampers understanding of its function and therapeutic potential. Cryogenic...

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Main Authors: Jasmin Baron, Lena Bauernhofer, Sandro Keller, Franz P. W. Radner, Carolyn Vargas, Gerd Leitinger, Lukas Bernauer, Anita Emmerstorfer-Augustin, Patrick Wiedner, Grégory Durand, Marine Soulié, Victoria Dorrer, Matthias Schittmayer, Ruth Birner-Gruenberger, Michaela Lichtenegger, Matthias Gsell, Klaus Groschner, Rainer Schindl, Oleksandra Tiapko
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Scientific Reports
Subjects:
TRPC3
Protein purification
Nanodiscs
Reconstitution
Electrophysiology
Online Access:https://doi.org/10.1038/s41598-025-13218-6
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https://doi.org/10.1038/s41598-025-13218-6

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