BRAF V600E in a preclinical model of pleomorphic Xanthoastrocytoma: Analysis of the tumor microenvironment and immune cell infiltration dynamics in vivo

BRAF V600E in a preclinical model of pleomorphic Xanthoastrocytoma: Analysis of the tumor microenvironment and immune cell infiltration dynamics in vivo

Low-grade glioma (LGG) is the most common brain tumor affecting pediatric patients (pLGG) and BRAF mutations constitute the most frequent genetic alterations. Within the spectrum of pLGGs, approximately 70%–80% of pediatric patients diagnosed with transforming pleomorphic xanthoastrocytoma (PXA) har...

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Bibliographic Details
Main Authors: Alessandro Canella, Matthew Nazzaro, Mykyta Artomov, Lakshmi Prakruthi Rao Venkata, Diana Thomas, Justin Lyberger, Aleksandr Ukhatov, Yao Lulu Xing, Katherine Miller, Gregory Behbehani, Nduka M. Amankulor, Claudia Katharina Petritsch, Prajwal Rajappa
Format: Article
Language:English
Published: Elsevier 2024-06-01
Series:Molecular Therapy: Oncology
Subjects:
TME
pLGG
PXA
BRAF V600E
RCAS
immunosuppression
Online Access:http://www.sciencedirect.com/science/article/pii/S295032992400050X
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