Synthesis and Biological Activity of Glycosyl Thiazolyl Disulfides Based on Thiacarpine, an Analogue of the Cytotoxic Alkaloid Polycarpine from the Ascidian <i>Polycarpa aurata</i>

Synthesis and Biological Activity of Glycosyl Thiazolyl Disulfides Based on Thiacarpine, an Analogue of the Cytotoxic Alkaloid Polycarpine from the Ascidian <i>Polycarpa aurata</i>

Polycarpine, a diimidazolyl disulfan alkaloid isolated from the ascidian <i>Polycarpa aurata</i>, showed high cytotoxic activity in vitro. However, in vivo experiments have shown that polycarpine has a high acute toxicity. At the same time, its synthetic thiazolyl analog, thiacarpine, sh...

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Main Authors: Dmitry N. Pelageev, Yuri E. Sabutski, Svetlana M. Kovach, Nadezhda N. Balaneva, Ekaterina S. Menchinskaya, Ekaterina A. Chingizova, Anna L. Burylova, Victor Ph. Anufriev
Format: Article
Language:English
Published: MDPI AG 2025-03-01
Series:Marine Drugs
Subjects:
polycarpine
thiacarpine
bis(2-amino-4-phenyl-5-thiazolyl)disulfide
thioglycosides
<i>Polycarpa aurata</i>
cytotoxic activity
Online Access:https://www.mdpi.com/1660-3397/23/3/117
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