MIF tautomerase inhibitor TE-11 prevents inflammatory macrophage activation and glycolytic reprogramming while reducing leukocyte migration and improving Crohn’s disease-like colitis in male mice

MIF tautomerase inhibitor TE-11 prevents inflammatory macrophage activation and glycolytic reprogramming while reducing leukocyte migration and improving Crohn’s disease-like colitis in male mice

Background & aimsCrohn’s disease (CD) is a chronic inflammatory disorder primarily affecting the gastrointestinal tract. Leukocyte recruitment, M1 macrophage polarization and associated metabolic reprogramming are hallmarks of its pathomechanism. Here, we tested TE-11, a potent MIF tautomera...

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Bibliographic Details
Main Authors: Eszter Vámos, Viola Bagóné Vántus, Péter Deák, Nikoletta Kálmán, Eva Maria Sturm, Barsha Baisakhi Nayak, Lilla Makszin, Tamás Loránd, Ferenc Jr Gallyas, Balázs Radnai
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-04-01
Series:Frontiers in Immunology
Subjects:
Crohn’s disease
MIF
macrophage activation
M1 polarization
metabolic reprogramming
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1558079/full
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https://www.frontiersin.org/articles/10.3389/fimmu.2025.1558079/full

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