Quality by design-based optimization and HP-TLC densitometric standardization of Theobroma cacao L. extract as a nutraceutical supplement

Quality by design-based optimization and HP-TLC densitometric standardization of Theobroma cacao L. extract as a nutraceutical supplement

BackgroundOur previous studies identified the hydroalcoholic extract of defatted Theobroma cacao L. bean (CE) as a cancer-preventive and a protective agent against chemotherapeutic-induced toxicities, specifically doxorubicin-induced heart, liver, and kidney toxicities.MethodsAn analytical method fo...

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Bibliographic Details
Main Authors: Atith Muppayyanamath, Darasaguppe R. Harish, Vinayak Mastiholimath, Priyanka P. Patil, Vishal S. Patil, Harsha V. Hegde, Subarna Roy
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-04-01
Series:Frontiers in Nutrition
Subjects:
quality by design
central composite design
HPTLC
Theobroma cacao L
EGCG (−)-epigallocatechin-3-gallate
nutraceuticals
Online Access:https://www.frontiersin.org/articles/10.3389/fnut.2025.1537963/full
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https://www.frontiersin.org/articles/10.3389/fnut.2025.1537963/full

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