STRaM: A genetic framework for improved cell product provenance for research and clinical translations

STRaM: A genetic framework for improved cell product provenance for research and clinical translations

Abstract Multiple assessment checks are required to handle the increasingly complex engineered-cell and cell-line provenance. To manage the biosafety and efficacy demands, we developed a bioinformatic pipeline for de novo profiling of short tandem repeats and mutations (STRaM) to identify and track...

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Main Authors: Binglin Li, Chi Le, Wen Lei, Yingqi Zhou, Ying Zhang, Yanwen Wang, Yanyan Wang, Xian Li, Weiyan Zheng, Jie Sun, Yuanbiao Tu, Wangren Yang, Kuncheng Zhou, Stephene S. Meena, Yufei Li, Keying Zhu, Shuqin Zhou, Liyan Liu, Hao Chen, Qing Peng, Wenbin Qian, Ray P. S. Han, Wei Guo
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-025-08547-1
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https://doi.org/10.1038/s42003-025-08547-1

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