Cross-lineage 5-methylcytosine methylome profiling reveals methylated divergence among Toxoplasma gondii tachyzoites of the three major clonal lineages

Cross-lineage 5-methylcytosine methylome profiling reveals methylated divergence among Toxoplasma gondii tachyzoites of the three major clonal lineages

Abstract Background Toxoplasma gondii is a globally widespread zoonotic parasite, infecting nearly one-third of the human population, often leading to chronic, latent infections. Among the emerging layers of gene regulation, 5-methylcytosine (m5C) has emerged as a pivotal post-transcriptional modifi...

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Main Authors: Xiao-Nan Zheng, Hong-Yu Song, Hany M. Elsheikha, Chen-Ran Tian, Xing Tian, Qing Liu, Wen-Bin Zheng, Xing-Quan Zhu
Format: Article
Language:English
Published: BMC 2025-08-01
Series:Infectious Diseases of Poverty
Subjects:
Toxoplasma gondii
Toxoplasmosis
5-methylcytosine
Methylated RNA immunoprecipitation sequencing
RNA sequencing
Epitranscriptomic regulation
Online Access:https://doi.org/10.1186/s40249-025-01358-w
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https://doi.org/10.1186/s40249-025-01358-w

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