Treg and intestinal myofibroblasts-derived Amphiregulin induced by TGF-β mediates intestinal fibrosis in Crohn’s disease

Treg and intestinal myofibroblasts-derived Amphiregulin induced by TGF-β mediates intestinal fibrosis in Crohn’s disease

Abstract Background Intestinal fibrosis is a serious complication of Crohn’s disease (CD), often resulting from chronic inflammation. However, the precise mechanisms through which inflammation induces intestinal fibrosis remain inadequately elucidated. Methods A comprehensive single-cell atlas of fu...

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Bibliographic Details
Main Authors: Lu Wang, Shu Wang, Junjie Lin, Jiajia Li, Mingyuan Wang, Jiang Yu, Junjian Sun, Nana Tang, Chunhua Jiao, Jingjing Ma, Xiaojing Zhao, Hongjie Zhang
Format: Article
Language:English
Published: BMC 2025-04-01
Series:Journal of Translational Medicine
Subjects:
Crohn’s disease
Intestinal fibrosis
Tregs
Fibroblast
Amphiregulin
Online Access:https://doi.org/10.1186/s12967-025-06413-6
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https://doi.org/10.1186/s12967-025-06413-6

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