Neuronal Deletion of <i>Tumor Susceptibility Gene 101</i> (<i>Tsg101</i>) Causes Rapid Apoptotic Loss of Hippocampal CA3 Neurons

Neuronal Deletion of <i>Tumor Susceptibility Gene 101</i> (<i>Tsg101</i>) Causes Rapid Apoptotic Loss of Hippocampal CA3 Neurons

Endosomal dysfunction is one of the earliest cellular signs in Alzheimer’s disease. Tumor susceptibility gene 101 protein (TSG101) is a component of the endosomal sorting complex required for transport (ESCRT)-I, which plays a key role in sorting ubiquitinated cell surface proteins and lipids onto i...

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Bibliographic Details
Main Authors: Will P. Walker, Megan Lea Ratz-Mitchem, Kay-Uwe Wagner, Teresa M. Gunn
Format: Article
Language:English
Published: MDPI AG 2025-05-01
Series:Biomolecules
Subjects:
<i>Tumor Susceptibility Gene 101</i> (<i>Tsg101</i>/TSG101)
endosomal trafficking
neurodegeneration
amyloid beta
Online Access:https://www.mdpi.com/2218-273X/15/6/786
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https://www.mdpi.com/2218-273X/15/6/786

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