ANO1 channels are expressed in mouse urethral smooth muscle but do not contribute to agonist or neurally evoked contractions

ANO1 channels are expressed in mouse urethral smooth muscle but do not contribute to agonist or neurally evoked contractions

Abstract Anoctamin-1 Ca2+-activated Cl− channels (ANO1) are proposed to modulate contractility of urethra smooth muscle cells (USMC), but their cellular expression and contribution to agonist/neural evoked activity is unclear. ANO1 is implicated as a potential target to treat incontinence, thus this...

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Bibliographic Details
Main Authors: Neha Gupta, Salah A. Baker, Kenton M. Sanders, Kaneez E. Rabab, Denzel KF. Thean, Tuleen Alkawadri, Caoimhin S. Griffin, Gerard P. Sergeant, Mark A. Hollywood, Keith D. Thornbury, Bernard T. Drumm
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Scientific Reports
Subjects:
Urethra
Ca2+-activated-Cl−
Smooth muscle
Incontinence
Ani9
ANO1
Online Access:https://doi.org/10.1038/s41598-025-00953-z
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https://doi.org/10.1038/s41598-025-00953-z

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