Impact of CD11c+ cells in conducting airway lumen on Aspergillus fumigatus conidia deposition in neutropenic mice

Impact of CD11c+ cells in conducting airway lumen on Aspergillus fumigatus conidia deposition in neutropenic mice

IntroductionInhaled conidia of the opportunistic fungi Aspergillus fumigatus settle in the airway mucosa and in alveolar spaces. Different immune cells typically provide crucial defense against fungal germination. However, in immunocompromised patients, the lack of sufficient pro-inflammatory immune...

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Main Authors: Mariia Pavelchenko, Svyatoslav Shalyapin, Sergey Portnov, Andrey Bogorodskiy, Elena Bolkhovitina, Vitalii Shevchenko, Alexander Sapozhnikov, Valentin Borshchevskiy, Marina Shevchenko
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Fungal Biology
Subjects:
neutrophil depletion
invasive aspergillosis mouse model
confocal laser-scanning microscopy
whole-mount lung imaging
Aspergillus fumigatus conidia distribution
conducting airway mucosa
Online Access:https://www.frontiersin.org/articles/10.3389/ffunb.2025.1591891/full
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https://www.frontiersin.org/articles/10.3389/ffunb.2025.1591891/full

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