Low dose radiotherapy combined with immune checkpoint inhibitors induces ferroptosis in lung cancer via the Nrf2/HO-1/GPX4 axis

Low dose radiotherapy combined with immune checkpoint inhibitors induces ferroptosis in lung cancer via the Nrf2/HO-1/GPX4 axis

BackgroundImmune checkpoint inhibitors (ICI) have revolutionized the therapeutic direction for lung cancer, yet their response rates remain unsatisfactory. Recently, the combination of ICI and low dose radiotherapy (LDR), a novel approach that effectively mobilizes innate and adaptive immunity, has...

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Bibliographic Details
Main Authors: Jing Luo, Qiongjie Zhi, Dongxia Li, Yue Xu, Hui Zhu, Lujun Zhao, Guibing Ren, Jian Wang, Ningbo Liu
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-05-01
Series:Frontiers in Immunology
Subjects:
low dose radiotherapy
immune checkpoint inhibitor
ferroptosis
Nrf2/HO-1/GPX4
chemoimmunotherapy-resistant
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1558814/full
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https://www.frontiersin.org/articles/10.3389/fimmu.2025.1558814/full

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