GPR56/ADGRG1 induces biased Rho-ROCK-MLC and JAK-STAT3 signaling to promote amoeboid-like morphology and IL-6 upregulation in melanoma cells

GPR56/ADGRG1 induces biased Rho-ROCK-MLC and JAK-STAT3 signaling to promote amoeboid-like morphology and IL-6 upregulation in melanoma cells

Abstract Background GPR56/ADGRG1 is an adhesion G protein-coupled receptor involved in cell-matrix interactions and metastasis of human melanoma cells. Previously, we demonstrated that GPR56 activation in melanoma cells triggers Gα12/13-RhoA signaling, leading to increased IL-6 production and enhanc...

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Main Authors: Kuan-Yeh Huang, Kwai-Fong Ng, Kuan-Yu I, Yu-Chi Chang, Hsin-Yi Chen, Ya-Fang Chiu, Chuan-Mao Hung, Wan-Chen Yu, Tse-Ching Chen, Martin Stacey, Hsi-Hsien Lin
Format: Article
Language:English
Published: BMC 2025-05-01
Series:Cell Communication and Signaling
Subjects:
Adhesion GPCR
IL-6
Cytoskeletal remodelling
GPR56
Melanoma
Signalling
Online Access:https://doi.org/10.1186/s12964-025-02267-z
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https://doi.org/10.1186/s12964-025-02267-z

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