Shaking culture attenuates circadian rhythms in induced pluripotent stem cells during osteogenic differentiation through the TEAD-Fbxl3-CRY axis

Abstract Circadian rhythms, which synchronize cellular and organismal activities with the Earth’s 24-hour light-dark cycle, are controlled by clock genes. These genes not only regulate metabolic and physiological processes but also influence osteogenesis. Despite extensive research on the genetic co...

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Bibliographic Details
Main Authors: Yunyu Fu, Hiroko Okawa, Naruephorn Vinaikosol, Satomi Mori, Phoonsuk Limraksasin, Praphawi Nattasit, Yu Tahara, Hiroshi Egusa
Format: Article
Language:English
Published: Nature Publishing Group 2025-05-01
Series:Cell Death Discovery
Online Access:https://doi.org/10.1038/s41420-025-02533-6
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