Triptolide targets PPP2CA/ITGA5 axis to suppress lactate-driven ovarian cancer progression

Triptolide targets PPP2CA/ITGA5 axis to suppress lactate-driven ovarian cancer progression

Abstract Background Triptolide, the active compound of Tripterygium wilfordii, exhibits broad anti-tumor activity. This study explores PPP2CA dysregulation in ovarian cancer (OC) progression via lactate production and evaluates Triptolide’s potential to regulate this process. Methods We used patient...

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Bibliographic Details
Main Authors: Ling Ding, Wutao Chen, Cenxin Luo, Nathaniel Weygant, Yi Lai, Dan Ru, Hengan Liu, You Wang, He Li
Format: Article
Language:English
Published: BMC 2025-08-01
Series:Chinese Medicine
Subjects:
Ovarian cancer
PPP2CA
ITGA5
Lactate
Triptolide
Online Access:https://doi.org/10.1186/s13020-025-01174-2
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https://doi.org/10.1186/s13020-025-01174-2

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