Ziziphi Spinosae Semen Flavonoid Ameliorates Hypothalamic Metabolism and Modulates Gut Microbiota in Chronic Restraint Stress-Induced Anxiety-like Behavior in Mice

Ziziphi Spinosae Semen Flavonoid Ameliorates Hypothalamic Metabolism and Modulates Gut Microbiota in Chronic Restraint Stress-Induced Anxiety-like Behavior in Mice

Ziziphi Spinosae Semen (ZSS), a homology of medicine and a type of seed, has been widely used to improve sleep quality. The present study aimed to assess the effects of ZSS flavonoid (ZSSF) extracted and isolated from ZSS on gut microbiota and hypothalamus metabolomic profiles in a chronic restraint...

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Bibliographic Details
Main Authors: Yan Yan, Ni Zhao, Jiaying Liu, Shengmei Zhang, Yinjie Zhang, Xuemei Qin, Kefeng Zhai, Chenhui Du
Format: Article
Language:English
Published: MDPI AG 2025-02-01
Series:Foods
Subjects:
Ziziphi Spinosae Semen flavonoid
anxiety
gut microbiota
amino acid metabolism
lipid metabolism
Online Access:https://www.mdpi.com/2304-8158/14/5/828
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