Peroxiredoxin 1-Toll-like receptor 4-p65 axis inhibits receptor activator of nuclear factor kappa-B ligand-mediated osteoclast differentiation

Peroxiredoxin 1-Toll-like receptor 4-p65 axis inhibits receptor activator of nuclear factor kappa-B ligand-mediated osteoclast differentiation

Summary: Peroxiredoxin 1 (PRDX1), an intracellular antioxidant enzyme, has emerged as a regulator of inflammatory responses via Toll-like receptor 4 (TLR4) signaling. Despite this, the mechanistic details of the PRDX1-TLR4 axis and its impact on osteoclast differentiation remain elusive. Here, we sh...

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Bibliographic Details
Main Authors: Jisu Park, Sanggil Kim, Hye-Yeon Jung, Eun Hwan Bae, Minhye Shin, Jae-Il Park, So-Young Choi, Sun-Ju Yi, Kyunghwan Kim
Format: Article
Language:English
Published: Elsevier 2024-12-01
Series:iScience
Subjects:
Cellular physiology
Molecular biology
Transcriptomics
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004224026828
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http://www.sciencedirect.com/science/article/pii/S2589004224026828

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