GABPA inhibits tumorigenesis in clear cell renal cell carcinoma by regulating ferroptosis through ACSL4

GABPA inhibits tumorigenesis in clear cell renal cell carcinoma by regulating ferroptosis through ACSL4

Abstract Clear cell renal cell carcinoma (ccRCC) is a common genitourinary malignancy characterized by dysregulated cellular metabolism leading to aberrant glucose metabolism, fatty acid accumulation, and excessive reactive oxygen species production. ccRCC cells exhibit an augmented oxidative stress...

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Bibliographic Details
Main Authors: Yaqian Wu, Zonglong Wu, Mengfei Yao, Li Liu, Yimeng Song, Lulin Ma, Cheng Liu
Format: Article
Language:English
Published: Nature Portfolio 2024-11-01
Series:Scientific Reports
Subjects:
GABPA
Tumorigenesis
Clear cell renal cell carcinoma
Ferroptosis
ACSL4
Online Access:https://doi.org/10.1038/s41598-024-78441-z
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https://doi.org/10.1038/s41598-024-78441-z

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