Gasdermin D aggravates a mouse model of radiation-induced liver disease by promoting chemokine secretion and neutrophil recruitment

Abstract Radiation-induced liver disease (RILD) severely impairs the outcome of patients receiving irradiation (IR); however, its underlying mechanism remains unknown. GSDMD drives the progression of pyroptosis, and can be induced by IR in the gut and bone marrow, but its role in RILD remains unknow...

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Bibliographic Details
Main Authors: Aoran Dong, Guangyan Wei, Zhou Liang, Yuqin Di, Yuhao Tang, Yunyan Ling, Shuping Li, Yong Chen, Yi Zhou, Xiongjun Wang, Zhenwei Peng
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-61397-7
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