Irisin‐mediated muscle‐renal crosstalk as a protective mechanism against contrast‐induced acute kidney injury via cGAS‐STING signalling inhibition

Irisin‐mediated muscle‐renal crosstalk as a protective mechanism against contrast‐induced acute kidney injury via cGAS‐STING signalling inhibition

ABSTRACT Background Contrast‐induced acute kidney injury (CI‐AKI) continues to pose a pressing clinical challenge during invasive cardiovascular procedures due to the limited availability of preventative strategies. We aimed to demonstrate that irisin, a myokine induced by exercise, protects against...

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Bibliographic Details
Main Authors: Long Peng, Suhua Li, Qiang Huang, Yuxiang Sun, Juan Sun, Ting Luo, Yanlin Wang, Zhaoyong Hu, Weiyan Lai, Hui Peng
Format: Article
Language:English
Published: Wiley 2025-03-01
Series:Clinical and Translational Medicine
Subjects:
cGAS‐STING
contrast‐induced acute kidney injury
inflammation
irisin
mPGC‐1α
Online Access:https://doi.org/10.1002/ctm2.70235
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https://doi.org/10.1002/ctm2.70235

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