Accurate Transcription Factor Activity Inference to Decipher Cell Identity from Single‐Cell Transcriptomic Data with MetaTF

Accurate Transcription Factor Activity Inference to Decipher Cell Identity from Single‐Cell Transcriptomic Data with MetaTF

Abstract Cellular heterogeneity within cancer tissues determines cancer progression and treatment response. Single‐cell RNA sequencing (scRNA‐seq) has provided a powerful approach for investigating the cellular heterogeneity of both cancer cells and stroma cells in the tumor microenvironment. Howeve...

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Bibliographic Details
Main Authors: Yongfei Hu, Yuanyuan Zhu, Guangjue Tang, Ming Shan, Puwen Tan, Ying Yi, Xiyuan Zhang, Man Liu, Xinyu Li, Le Wu, Jia Chen, Hailong Zheng, Yan Huang, Zhuan Li, Xiaobo Li, Dong Wang
Format: Article
Language:English
Published: Wiley 2025-06-01
Series:Advanced Science
Subjects:
cell identity
scRNA‐seq
transcription factor activity
tumor immune microenvironment
Online Access:https://doi.org/10.1002/advs.202410745
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https://doi.org/10.1002/advs.202410745

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