Ephrin-B2 deletion in GABAergic neurons induces cognitive deficits associated with single-nucleus transcriptomic differences in the prefrontal cortex

Ephrin-B2 deletion in GABAergic neurons induces cognitive deficits associated with single-nucleus transcriptomic differences in the prefrontal cortex

Abstract Background Ephrin-B2 (EB2) signaling plays a crucial role in regulating memory and synaptic plasticity. Comprehensive identification of cell-type-specific transcriptomic changes in EB2 knockout mice is expected to shed light on potential mechanisms associated with EB2 signaling in cognitive...

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Main Authors: Peijun Ju, Yu Fang, Siying Xiang, Weidi Wang, Ying Sun, Wei Wang, Yanli Ding, Chao Luo, Ping Jiang, Jianhua Chen
Format: Article
Language:English
Published: BMC 2025-08-01
Series:BMC Biology
Subjects:
Ephrin-B2
Cognition
Single-nucleus RNA sequencing
GABAergic neurons
Online Access:https://doi.org/10.1186/s12915-025-02333-5
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https://doi.org/10.1186/s12915-025-02333-5

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