Evolution of ceftazidime-avibactam resistance driven by variation in blaKPC-2 to blaKPC-190 during treatment of ST11-K64 hypervirulent Klebsiella pneumoniae

Evolution of ceftazidime-avibactam resistance driven by variation in blaKPC-2 to blaKPC-190 during treatment of ST11-K64 hypervirulent Klebsiella pneumoniae

IntroductionThe emergence of Klebsiella pneumoniae carbapenemase (KPC) variants has significantly compromised the efficacy of ceftazidime-avibactam (CZA), a critical antibiotic for treating carbapenem-resistant K. pneumoniae (CRKP) infections. This study investigates the novel KPC-190 variant, ident...

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Main Authors: Zeshi Liu, Jing Lei, Xue Zhang, Jian Yin, Yanping Zhang, Ke Lei, Yan Geng, Lingjuan Huang, Qiang Han, Aili He
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
KPC-190
Klebsiella pneumoniae
ceftazidime-avibactam
blaKPC variants
antibiotic resistance
Online Access:https://www.frontiersin.org/articles/10.3389/fcimb.2025.1607127/full
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https://www.frontiersin.org/articles/10.3389/fcimb.2025.1607127/full

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