Exploiting induced pluripotent stem cell-derived retinal pigment epithelium to unravel host-pathogen interaction in ocular tuberculosis: a reverse translational in vitro model

Exploiting induced pluripotent stem cell-derived retinal pigment epithelium to unravel host-pathogen interaction in ocular tuberculosis: a reverse translational in vitro model

Mycobacterium tuberculosis (Mtb) can infect the retinal pigment epithelium (RPE) cells. Current in vitro research models for ocular tuberculosis (OTB) only rely on RPE cell culture approaches. Until now it remains unclear why only a minority of patients with active systemic tuberculosis (TB) develop...

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Main Authors: Ikhwanuliman Putera, Sanne van de Meerendonk, Nicole M.A. Nagtzaam, Rina La Distia Nora, Saskia M. Rombach, Jurriaan E.M. de Steenwinkel, Johannes R. Vingerling, Willem A. Dik, P. Martin van Hagen
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Ophthalmology
Subjects:
induced pluripotent stem cells
personalized medicine
retinal pigment epithelium
uveitis
tuberculosis
Online Access:https://www.frontiersin.org/articles/10.3389/fopht.2025.1610215/full
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https://www.frontiersin.org/articles/10.3389/fopht.2025.1610215/full

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