Computational drug discovery of phytochemical alkaloids targeting the NACHT/PYD domain in the NLRP3 inflammasome

Computational drug discovery of phytochemical alkaloids targeting the NACHT/PYD domain in the NLRP3 inflammasome

Abstract The NLRP3 inflammasome plays a pivotal role in the innate immune system, orchestrating the activation of caspase-1 and the release of proinflammatory cytokines IL-1β and IL-18 in reaction to microbial infections and cellular damage. Despite its crucial function in defending against pathogen...

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Bibliographic Details
Main Authors: Nilay Singh, Promila Sharma, Manoj K. Pal, Ragini Kahera, Himani Badoni, Kumud Pant, Neetu Sharma, Bhawana Bhist
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Scientific Reports
Subjects:
In silico
NLRP3
ADMET
Docking
Alkaloids
STRING
Online Access:https://doi.org/10.1038/s41598-024-79054-2
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https://doi.org/10.1038/s41598-024-79054-2

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