Catalpol alleviates amyloid- generation and neuronal oxidative stress injury via activating the Keap1-Nrf2/ARE signaling pathway in the immortalized lymphocytes from patients with late-onset Alzheimer’s disease and SKNMC cells co-culture model

Catalpol alleviates amyloid- generation and neuronal oxidative stress injury via activating the Keap1-Nrf2/ARE signaling pathway in the immortalized lymphocytes from patients with late-onset Alzheimer’s disease and SKNMC cells co-culture model

Objective(s): To assess the effect of catalpol, the major bioactive constituents of Rehmannia glutinosa, on our Alzheimer’s disease (AD) in vitro model.Materials and Methods: We employed the immortalized lymphocytes (lymphoblastoid cell line, LCL) from late-onset AD patients and co-cultured “them” t...

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Bibliographic Details
Main Authors: Caixia Xiang, Yunwei Lu, Renjuan Hao, Yuyan Wei, Yingchao Hu, Guran Yu
Format: Article
Language:English
Published: Mashhad University of Medical Sciences 2024-12-01
Series:Iranian Journal of Basic Medical Sciences
Subjects:
alzheimer’s disease
amyloid beta-peptides
apoptosis
catalpol
oxidative stress
Online Access:https://ijbms.mums.ac.ir/article_24756_a7ef5d44bb28e4a00ebe6c71d9b21217.pdf
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https://ijbms.mums.ac.ir/article_24756_a7ef5d44bb28e4a00ebe6c71d9b21217.pdf

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