Stereoselectivity of Yeast Reductions - an Improved Procedure for the Preparation of Ethyl (S)-3-Hydroxybutanoate and (S)-2-Hydroxymethylbutanoate
Ethyl 3-oxo- and 2-formyl-butanoate (4-5 g/L) are reduced in ca. 70% yield to the title compounds of > 90% enantiomeric excess by baker’s yeast (125 g/L) which had been kept in 5 % aqueous ethanol with shaking under aerobic conditions in the absence of sugar for four days.
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | deu |
| Published: |
Swiss Chemical Society
1986-05-01
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| Series: | CHIMIA |
| Online Access: | https://www.chimia.ch/chimia/article/view/9732 |
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