HLA-F regulates the proliferation of trophoblast via PKM2-dependent glycolysis in the pathogenesis of preeclampsia

HLA-F regulates the proliferation of trophoblast via PKM2-dependent glycolysis in the pathogenesis of preeclampsia

Abstract Background The regulatory molecule Human Leukocyte Antigen F (HLA-F) has been implicated in trophoblast proliferation during pregnancy, and reduced levels of this antigen have been identified in trophoblast cells of patients with preeclampsia. This study aimed to analyze the effect and mech...

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Bibliographic Details
Main Authors: Ruiling Xu, Yu Huang, Wenchi Xie, Dan Luo, Jie Mei, Xinghui Liu, Fulin Liu, Fangyuan Luo
Format: Article
Language:English
Published: BMC 2025-04-01
Series:Molecular Medicine
Subjects:
Preeclampsia
HLA-F
Trophoblast
Proliferation
PKM2
Lactylation
Online Access:https://doi.org/10.1186/s10020-025-01201-w
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https://doi.org/10.1186/s10020-025-01201-w

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