Modulation of Astrocytes on Mode Selection of Neuron Firing Driven by Electromagnetic Induction
Both of astrocytes and electromagnetic induction are magnificent to modulate neuron firing by introducing feedback currents to membrane potential. An improved astro-neuron model considering both of the two factors is employed to investigate their different roles in modulation. The mixing mode, defin...
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/2020/8899577 |
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| author | Zhongquan Gao Zhixuan Yuan Zuo Wang Peihua Feng |
| author_facet | Zhongquan Gao Zhixuan Yuan Zuo Wang Peihua Feng |
| author_sort | Zhongquan Gao |
| collection | DOAJ |
| description | Both of astrocytes and electromagnetic induction are magnificent to modulate neuron firing by introducing feedback currents to membrane potential. An improved astro-neuron model considering both of the two factors is employed to investigate their different roles in modulation. The mixing mode, defined by combination of period bursting and depolarization blockage, characterizes the effect of astrocytes. Mixing mode and period bursting alternatively appear in parameter space with respect to the amplitude of feedback current on neuron from astrocyte modulation. However, magnetic flux obviously plays a role of neuron firing inhibition. It not only repels the mixing mode but also suppresses period bursting. The mixing mode becomes period bursting mode and even resting state when astrocytes are hyperexcitable. Abnormal activities of astrocytes are capable to induce depolarization blockage to compose the mixing mode together with bursting mode. But electromagnetic induction shows its strong ability of inhibition of neuron firing, which is also illustrated in the bifurcation diagram. Indeed, the combination of the two factors and appropriate choice of parameters show the great potential to control disorder of neuron firing like epilepsy. |
| format | Article |
| id | doaj-art-f74d844ee1d24c33b662e7e2f6b3ed1b |
| institution | Kabale University |
| issn | 2090-5904 1687-5443 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neural Plasticity |
| spelling | doaj-art-f74d844ee1d24c33b662e7e2f6b3ed1b2025-02-03T01:20:09ZengWileyNeural Plasticity2090-59041687-54432020-01-01202010.1155/2020/88995778899577Modulation of Astrocytes on Mode Selection of Neuron Firing Driven by Electromagnetic InductionZhongquan Gao0Zhixuan Yuan1Zuo Wang2Peihua Feng3School of Power and Energy Engineering, Xi’an Jiaotong University, Xi’an, Shaanxi 710049, ChinaState Key Laboratory for Strength and Vibration of Mechanical Structures, School of Aerospace Engineering, Xi’an Jiaotong University, Xi’an 710049, ChinaSchool of Power and Energy Engineering, Xi’an Jiaotong University, Xi’an, Shaanxi 710049, ChinaState Key Laboratory for Strength and Vibration of Mechanical Structures, School of Aerospace Engineering, Xi’an Jiaotong University, Xi’an 710049, ChinaBoth of astrocytes and electromagnetic induction are magnificent to modulate neuron firing by introducing feedback currents to membrane potential. An improved astro-neuron model considering both of the two factors is employed to investigate their different roles in modulation. The mixing mode, defined by combination of period bursting and depolarization blockage, characterizes the effect of astrocytes. Mixing mode and period bursting alternatively appear in parameter space with respect to the amplitude of feedback current on neuron from astrocyte modulation. However, magnetic flux obviously plays a role of neuron firing inhibition. It not only repels the mixing mode but also suppresses period bursting. The mixing mode becomes period bursting mode and even resting state when astrocytes are hyperexcitable. Abnormal activities of astrocytes are capable to induce depolarization blockage to compose the mixing mode together with bursting mode. But electromagnetic induction shows its strong ability of inhibition of neuron firing, which is also illustrated in the bifurcation diagram. Indeed, the combination of the two factors and appropriate choice of parameters show the great potential to control disorder of neuron firing like epilepsy.http://dx.doi.org/10.1155/2020/8899577 |
| spellingShingle | Zhongquan Gao Zhixuan Yuan Zuo Wang Peihua Feng Modulation of Astrocytes on Mode Selection of Neuron Firing Driven by Electromagnetic Induction Neural Plasticity |
| title | Modulation of Astrocytes on Mode Selection of Neuron Firing Driven by Electromagnetic Induction |
| title_full | Modulation of Astrocytes on Mode Selection of Neuron Firing Driven by Electromagnetic Induction |
| title_fullStr | Modulation of Astrocytes on Mode Selection of Neuron Firing Driven by Electromagnetic Induction |
| title_full_unstemmed | Modulation of Astrocytes on Mode Selection of Neuron Firing Driven by Electromagnetic Induction |
| title_short | Modulation of Astrocytes on Mode Selection of Neuron Firing Driven by Electromagnetic Induction |
| title_sort | modulation of astrocytes on mode selection of neuron firing driven by electromagnetic induction |
| url | http://dx.doi.org/10.1155/2020/8899577 |
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