A Causal Inference Approach to Mediation Analysis in Vitreomacular Traction: How Much Does Traction Resolution Mediate Functional Outcomes?

A Causal Inference Approach to Mediation Analysis in Vitreomacular Traction: How Much Does Traction Resolution Mediate Functional Outcomes?

Modern mediation analysis techniques supplement the primary intention-to-treat analysis with the aim to shed light onto the treatment mechanism. We investigate to what extent the anatomic marker vitreomacular adhesion resolution (VMAR) mediates vision benefits, comparing ocriplasmin vs. a sham regim...

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Bibliographic Details
Main Authors: Benedicte Lescrauwaet, Stijn Vansteelandt, Timothy L. Jackson, SriniVas R. Sadda, Luc Duchateau
Format: Article
Language:English
Published: MDPI AG 2024-09-01
Series:Journal of Market Access & Health Policy
Subjects:
anatomic outcomes
functional outcomes
biomarker
causal mediation analysis
patient-reported outcomes
vitreomacular adhesion/traction
Online Access:https://www.mdpi.com/2001-6689/12/4/22
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