Mechanism of hyperbaric oxygen therapy downregulating H-type angiogenesis in subchondral bone of knee osteoarthritis through the PHD2/HIF-1α pathway

Mechanism of hyperbaric oxygen therapy downregulating H-type angiogenesis in subchondral bone of knee osteoarthritis through the PHD2/HIF-1α pathway

Abstract Objective To explore the mechanism of hyperbaric oxygen therapy in inhibiting subchondral bone angiogenesis and delaying the progression of osteoarthritis through the PHD2/HIF-1α signaling pathway. Methods Mice were randomly divided into three groups (control group, osteoarthritis group, an...

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Bibliographic Details
Main Authors: Jianjian Wang, Wen Yu, Yuxin Zhang, Bo Chen, Zhaoxiang Meng
Format: Article
Language:English
Published: BMC 2025-01-01
Series:Journal of Orthopaedic Surgery and Research
Subjects:
Hyperbaric oxygen therapy
Osteoarthritis
PHD2
HIF-1α
Angiogenesis
Online Access:https://doi.org/10.1186/s13018-025-05514-8
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https://doi.org/10.1186/s13018-025-05514-8

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