CTLA-4 blockade and interferon-α induce proinflammatory transcriptional changes in the tumor immune landscape that correlate with pathologic response in melanoma.

CTLA-4 blockade and interferon-α induce proinflammatory transcriptional changes in the tumor immune landscape that correlate with pathologic response in melanoma.

Patients with locally/regionally advanced melanoma were treated with neoadjuvant combination immunotherapy with high-dose interferon α-2b (HDI) and ipilimumab in a phase I clinical trial. Tumor specimens were obtained prior to the initiation of neoadjuvant therapy, at the time of surgery and progres...

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Main Authors: Arjun Khunger, Erin Piazza, Sarah Warren, Thomas H Smith, Xing Ren, Andrew White, Nathan Elliott, Alessandra Cesano, Joseph M Beechem, John M Kirkwood, Ahmad A Tarhini
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2021-01-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0245287&type=printable
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https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0245287&type=printable

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